We put both in and im currently 8weeks pregnant. Check here for the full glossary (please excuse the repeated terms!). A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Use of this site is subject to our terms of use and privacy policy. Thank you! ERA testing. Learn more about, Learn About What to Expect's Pregnancy & Baby App. MENTS my 3rd FET was a success end MENTS. I know I needed it after my failed FET and I really didnt have it. (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). Theper retrievalstatistic helps to see the chancesbefore PGStesting. Normally, we have 23 pairs of chromosomes (or 46 in total) one pair comes from the egg from our biological mother, and the other comes from the sperm from our biological father. 2014). I was told by my doctor that when it is a PGS embryo that is miscarried, it is a 50% chance it was something else with the embryo (structural issues with the organs or placenta) and a 50% chance it was something about the moms body. 144 abnormal (aneuploid/mosaic) embryos and their outcomes. Do you think it's worth it as last time I had a medicated cycle and it was a . It worked and now Im 24 weeks pregnant with twins! think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. There was also no difference with Day 7, although the sample size was very small. The protocol was exactly the same as with the chemical pregnancy with addition of baby aspirin. Do the birth success rates of pgs tested embryos include both those that get a positive pregnancy test and those that dont? Then for my second FET we did an unmedicated FET and it worked. , Ive done embryo glue every transfer but no luck unfortunately :(. Consult with your doctor before making any treatment changes. Is it significantly less for a pregnancy with an embryo that tested pgt normal? We know about the epigenetic issue from testing the sperm but its not a test that you can do on the embryos (would have to kill them), I hope you are able to figure out what is going wrong and fix it! If you did PGS after multiple miscarriages and failed attempts how many did you transfer? Im still u sure if this will go to term, but getting a 2nd opinion from a specialist in RPL sure has made a difference. PGS Normal FET Results in Chemical Pregnancy *with* autoimmune protocol, Need some Love!!! MENTS my FET following that one was successful and I am now 28 weeks pregnant END MENTS .This whole IVF journey takes so much out of you and I truly feel your pain but please keep trying. Thanks for sharing! The RE I ended up with said "lets fight for this!" 2 - IUIs both chemical I was more relaxed overall at the second transfer, and maybe that helped. thank you for sharing! To count these women in, we can look at the per retrievaldata: Now when we look at everyone the stats look much different! Well start with euploids, then mosaics, and end with fully aneuploid embryos. Reply Share React operationpepper Dec 22, 2015 3:42 PM Gearing up for FET I went into my second egg retrieval and got less eggs than the first time around. However, this study did not focus on the >35 age group, which is likely to be the most benefited by this technique. Thank you Its so hard when youre paying yet your doctor doesnt think its needed. However we now understand that the chromosomes are only part of the issue. IVF/ICSI #3 another chemical with two frozen embryos left over. Im sure that data exists especially since thats how things used to be done back in the day. - 2 Day 5's transferred ended in a chemical pregnancy; 1 perfect Day 6 blast ended up making me a mom. I think it would be worth it to do a endometrial receptivity analysis to test your implantation window. If I had transferred two without PGS, there would have been a significant chance that both would have been abnormal. There is much better chance of IVF success with PGS testing in women who were over the age of 35. As for boosting chances with two put back it should not be the trick. Best of luck on your next FET! Thanks for commenting! I find the live birth rates by transfer versus by retrieval data very interesting. We timed everything to my cycle. I've experienced 3 chemical pregnancies - one naturally (7/2017), one via our 2nd IUI (9/2018), and the third this January after our FET with a PGS tested embryo. For these groups, about 50% of biopsies had noeuploidembryos. Embryos with the right number of chromosomes are called euploid and may have a higher chance of making a pregnancy, although the evidence for this is controversial. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. I dont know if this is helpful or not but Ive had 4 FETs. This November I did a frozen transfer with an untested, five day embryo and Im 9 weeks now. MENTS our next transfer was successful and I'm coming up on 12 weeks. At this point I am waiting to start my 5th miscarriage. I'm so sorry for your loss. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Hi.all0130could you tell me what kind of endometrial scratch biospy you did?hi.T3bk.you did endometrial scratch biospy too?which one you did?era.yale eft.or something else? Please specify a reason for deleting this reply from the community. Did you do anything different with your FET? After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. Saw a heartbeat at 6 and 8 weeks then nothing at week 10. Next Generation Sequencing (NGS) is a new technique which boasts an impressive 99.98% consistency rate for its results. But wait! Last January we found out we were pregnant but had a miscarriage at 7 weeks. (2018)looked at about 650 transfers ofPGS tested euploidembryos (based onSNPtechnology) across various ages: So it looks like the success rates hover around 60-70% in most cases, with women >42 having about a 50% live birth rate per transfer. I am hoping number 5 is it. Unfortunately this isnt very clear at this point. Your experience gives me hope so thank you for sharing , - Estradiol patches and to apply 4 of them and change them every 2 days, - progesterone 200mg suppository morning and evening. Which was Claritin, pepcid, and baby aspirin. I feel so lucky that I found this community. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. my first 2 cycles were artificial but my last 2 were natural and unfortunately no luck :( Hopefully we can get somewhere with the ERA. Terms are highlighted every 3rd time to avoid repetition. For your second question, Ill be doing an Embryo News this week that explains a study that compares non-PGS vs PGS tested embryos. I hope the ERA works too. And congratulations on your pregnancy!! Out of the 6 that were pgs tested, 3 came back normal and 1 came back inconclusive. I also know that no one can make this decision for me. If youre confused about the terminology youll see coming up, check my post on understanding PGS testing results. We have some sort of make factor at play but no other known fertility issues. I have a whole page dedicated to mosaic embryos. I feel like your doctor should have mentioned the ERA and biopsy by now. My first FET was a day 6 5AA euploid embryo. Good luck. Congratulations on your success , I have a similar story. Besides that, there are no gaurantees of both sticking. My RE also encouraged us to just try another transfer rather than an ERA after our first chemical but then was on board after the second chemical happened. While my clinic has had great success with PGS transfers they did say they expect implantation rates to end up averaging 90% for PGS normal embryos and I believe miscarriage rates are also lower. PGT-A meta-analysis finds live birth rates only improve with older patients, Complete Guide to Embryo Grading and Success Rates, PGS testing doesnt improve success in good prognosis patients, No difference in euploid and mosaic embryo transfers: a clinical trial, Embryo biopsy of small embryos dramatically reduces IVF success rates, 144 abnormal (aneuploid/mosaic) embryos and their outcomes, Overall there was no statistical difference in miscarriage rates (9.9% in the, For women <35 years old, there was no statistical difference (11.2% for. They found that: If you want to read my summary of this paper, check here. I don't know how many more cycles I can do as my emotional reserve is running low. I had also changed from an estradiol tablet to estradiol patches in my first FET. Hello, The usefulness comes when someone who is starting IVF and considering PGS testing. You have to do whatever you feel comfortable with and its so unfortunate that money plays a huge role in these decisions. Note that this is per transfer data. Talk about adjusting meds? I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. In this case the clinic will need to: So the embryo would have to go through multiple rounds of freezing/thawing/biopsy, and this might have an impact on its potential. Thankful for these forums! Does this harm the embryo or reduce its potential for success? Has anyone had a similar experience but had a viable pregnancy. yes! My doctor really only wants me to transfer one embryo, my husband and I want to do 2. (2016)looked at over 18,000 Day 5 embryo biopsies (usingthe older SNP technology) and reported the chances of an embryo beingeuploid(based on age): So up until 37 theres about a 50% chance of each blastocyst being a euploid, this cuts in half to about 25% at 42. MENTS We were devastated after our first pgs transfer ended in a chemical, and unfortunately we went on to have one more before finding success. However, I just recently gave birth, so dont give up there are still lots of reasons to be hopeful esp if you make pgs normal blasts. END MENT And the fact that the embryo's are at least starting to implant is confusing me in relation to my lining - Does that mean that my thinner lining is OK? (I was taking baby aspirin and Lovenox 2x/day for blood clotting disorders as well as Prednisone 30 mg /day and Intralipid transfusions weekly for elevated NK cells). We had 4 blasts tested in our first IVF cycle and 2 were abnormal / 1 mosaic / and then 1 "normal". So in your case it might be different since yours are chemical pregnancies but still worth asking I think :) Also someone above mentioned the endometrial biopsy which would also probably be a good idea. thanks so much! Weve spent almost 45K on this process and we are with a reputable clinic affiliated with CCRM so I am confident they know what they are doing but you cant also help but wonder is there more that can be done Im waiting to hear from the team to see if shes given some more thoughts. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). So most <35 women are between 30-90% chance ofeuploid(61% is the average). I think whats missing is the success rates for transfers of non PGS tested embryos. Fast Facts About PGS Testing Risks. This is my second failure of a PGS tested embryo, and the first on this immune suppressing protocol. Lack of common pregnancy symptoms like morning sickness or breast soreness after a positive pregnancy test. Thanks! So crazy that its what finally worked. My current success was a FET with NO meds except vaginal progesterone. Miscarriage of PGT tested embryo. After multiple necessary hysteroscopies, multiple retrievals, multiplefailed transfers, and 2 chemical pregnancies, I finally decided to get a 2nd opinion. (2017)had similar results to above (aCGH, women <35): Capalbo et al. I plan on asking my RE for a Recurrent loss panel to be done and autoimmune testing (NK cells etc)and a different protocol. It was an incredibly long and intense process but looking back I did not have time on my side for my eggs so it was the right decision for us. I am just torn. END MENTS We really expected to find success with our first pgs transfer even though our company and RE only quoted 60% odds per embryo transferits a good but tough reminder that its not expected to always work.
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